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Genome-wide analysis of M1 and M2 polarized macrophages with CNI-1493 treatment
Internal Dataset- Authors
- Anthony HeskethCaroline MaloneyChristopher BehrMorris Edelman5 more author(s)...
- Description
The purpose of this microarray is to identify genes that may be differentially expressed in M1 or M2 macrophages after treatment with CNI-1493. CNI-1493 is a known inhibitor of M1 macrophages but details of its molecular mechanism are unknown. The effect of CNI-1493 on M2 macrophages has yet to be explored, but we hypothesize that CNI-1493 treatment will attenuate pro-tumor properties of M2 macrophages....
- Subject
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CancerGenomicsmice
- Access Rights
- Free to All
- Local Expert
- Bettie Steinberg
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Autoantigen promotes progression to aggressive TCL1 leukemia
Internal Dataset- Authors
- Shih-Shih ChenFranak BatliwallaNichol HolodickXiao-Jie Yan4 more author(s)...
- Description
(Auto)antigen engagement by the B-cell receptor (BCR) and possibly the sites where this occurs influence the outcome of chronic lymphocytic leukemia (CLL). To test if selection for autoreactivity leads to increased aggressiveness and if this selection plays out equally in primary and secondary tissues, we used T-cell leukemia (TCL)1 cells reactive with the autoantigen phosphatidylcholine (PtC). After...
- Subject
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GenomicsLeukemiaSelection, Genetic
- Access Rights
- Free to All
- Local Expert
- Nicholas ChiorazziShih-Shih Chen
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- Genomics 2
- Cancer 1
- Leukemia 1
- Selection, Genetic 1
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